Aggressive cancer warning signs revealed after JFK’s granddaughter's diagnosis

Days aft Tatiana Schlossberg announced that she has terminal cancer, the spotlight is connected the informing signs of acute myeloid leukemia (AML).

John F. Kennedy’s granddaughter, 35, shared the details of her diagnosis successful an effort published successful The New Yorker connected Nov. 22.

Schlossberg, who is the girl of Kennedy’s daughter, Caroline Kennedy, and Edwin Schlossberg, learned of her illness successful May 2024. 

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She wrote that 1 doc predicted she would unrecorded for astir a year.

The archetypal indicator of Schlossberg’s illness was an abnormally precocious achromatic humor compartment count, which doctors detected conscionable hours aft she gave commencement to her 2nd child.

John F. Kennedy’s granddaughter, 35, shared the details of her diagnosis successful an effort published successful The New Yorker connected Nov. 22. She's pictured present successful 2023.  (AP Newsroom)

What is acute myeloid leukemia?

AML is simply a benignant of leukemia that begins successful the bony marrow, the soft, interior insubstantial of definite bones wherever caller humor cells are produced, according to the American Cancer Society.

This benignant of crab typically spreads rapidly from the bony marrow into the bloodstream and tin besides scope different parts of the body, specified arsenic the lymph nodes, liver, spleen, encephalon and spinal cord, and testicles, per ACS.

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In immoderate cases, clusters of leukemia cells whitethorn signifier a coagulated wide known arsenic a myeloid sarcoma.

Schlossberg's AML stems from a uncommon cistron mutation known arsenic inversion 3, which is an abnormality of chromosome 3 successful the leukemia cells.

Schlossberg, the girl of Caroline Kennedy (left) and Edwin Schlossberg, learned of her illness successful May 2024. (Getty Images)

"Inversion 3 correlates with a precise precocious complaint of absorption to modular chemotherapy treatments and, therefore, precise mediocre objective outcomes," Dr. Stephen Chung, a leukemia adept and oncologist astatine UT Southwestern Medical Center successful Dallas, Texas, told Fox News Digital. (Chung was not progressive successful Schlossberg’s care.)

Red flags and hazard factors

The astir communal symptoms of Schlossberg’s benignant of crab see abrupt onset of terrible fatigue, shortness of enactment with exertion, antithetic bleeding oregon bruising, fever and infections, according to Dr. Pamela Becker, prof successful the Division of Leukemia astatine City of Hope, a U.S. crab probe and attraction enactment successful California, who besides did not dainty Schlossberg.

AML tin sometimes lucifer a terrible flu with a mostly unwell feeling. 

Chung noted that AML usually causes abnormally debased humor compartment counts, oregon successful immoderate cases an abnormally precocious achromatic humor compartment count.

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"This whitethorn beryllium picked up successful regular investigating for different purposes, oregon due to the fact that the diligent develops symptoms from these debased humor counts," helium said. 

AML tin sometimes lucifer a terrible flu with a mostly unwell feeling, noted Robert Sikorski, M.D., Ph.D., a hematology/oncology adept and main aesculapian serviceman of Cero Therapeutics successful California. 

"Some patients besides acquisition bony symptom oregon nighttime sweats," helium told Fox News Digital.

Standing extracurricular the John F. Kennedy Library successful Boston, from left, Edwin Schlossberg, Rose Schlossberg, Victoria Reggie Kennedy, Ted Kennedy, Tatiana Schlossberg and Caroline Kennedy Schlossberg. Tatiana Schlossberg said a doc gave her an estimated 1 twelvemonth to live. (Getty Images)

Known hazard factors for AML see anterior chemotherapy oregon radiation, smoking, semipermanent benzene vulnerability and definite inherited syndromes, though astir cases hap without immoderate identifiable cause, according to Sikorski, who has not treated Schlossberg.

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In immoderate uncommon cases, radical tin inherit mutations that origin AML to tally successful families, with caller probe suggesting that these cases whitethorn beryllium much communal than antecedently thought, Chung noted.

"We utilized to lone cheque for this successful younger AML patients, but we present judge each patients should beryllium screened for these mutations," helium said.

Treatment for AML

The modular attraction for AML is intensive chemotherapy with a operation of 2 drugs, with further agents added based connected each patient’s circumstantial characteristics, according to Becker.

"We present judge each patients should beryllium screened for these mutations."

For patients with higher-risk types of AML, the chemotherapy is usually followed by a stem compartment (bone marrow) transplant to forestall relapse. The transplants travel from matched donors, often household members.

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"This is simply a overmuch much progressive process that usually involves different period successful the hospital, followed by adjacent follow-up for galore months, arsenic good arsenic a overmuch higher hazard for treatment-related broadside effects," Chung said.

There is not a circumstantial attraction that is effectual for Schlossberg’s circumstantial chromosome abnormality, the doctors noted, though immoderate caller cellular therapies and immunotherapies are being investigated.

Caroline Kennedy's children, Jack and Tatiana Schlossberg, and her hubby Edwin Schlossberg are pictured connected Capitol Hill successful 2013. The archetypal indicator of Schlossberg’s illness was an abnormally precocious achromatic humor compartment count, which doctors detected conscionable hours aft she gave commencement to her 2nd kid successful 2024. (Getty Images)

For older patients who are not beardown capable to person intensive chemotherapy, the modular attraction is venetoclax/azacytidine (a operation therapy utilized to dainty definite types of AML), Chung said.

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"This tin often beryllium fixed mostly extracurricular the infirmary connected a monthly basis," helium said. "While it technically is not considered to beryllium curative, it tin enactment precise good — successful immoderate cases, patients stay successful remission for galore months, if not years."

Hope ahead

There is anticipation connected the horizon, arsenic AML attraction has precocious much successful the past decennary than successful the erstwhile 30 years, according to Sikorski.

Caroline Kennedy is pictured with her children Rose Schlossberg (left), Tatiana Schlossberg (center) and Jack Schlossberg astatine the 2008 Democratic Convention successful Denver, Colorado. There is anticipation connected the skyline for AML treatment, doctors say. (Getty Images)

"New targeted drugs person been approved successful respective AML subtypes, and aboriginal enactment successful immune-based therapies, including CAR-T and different engineered compartment therapies, is opening to scope objective trials for AML," Sikorski, told Fox News Digital.

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"Supportive attraction has besides improved significantly, which helps patients tolerate attraction much effectively." 

While determination is not yet a cause tailored specifically to inversion 3, helium reiterated, "many studies focused connected high-risk AML are actively enrolling these patients, and the wide attraction scenery continues to expand."