Marijuana compound may help prevent dementia when paired with common drug

As marijuana's imaginable wellness benefits are nether debate, caller probe has recovered that THC could person a almighty and affirmative effect connected the brain.

Researchers astatine the University of Texas (UT) astatine San Antonio, Long School of Medicine, precocious discovered that THC (tetrahydrocannabinol, the main psychoactive compound successful marijuana) could forestall the improvement of Alzheimer’s illness – but lone erstwhile paired with an anti-inflammatory cause called celecoxib.

Celecoxib is simply a selective COX-2 inhibitor that is commonly prescribed for arthritis and pain.

ALZHEIMER’S DECLINE COULD SLOW DRAMATICALLY WITH ONE SIMPLE DAILY HABIT, STUDY FINDS

While THC has antecedently been shown to person anti-inflammatory and neuroprotective properties, it’s besides been linked to antagonistic effects connected the brain, peculiarly successful learning and memory, according to a UT Health property release.

Combining THC with an anti-inflammatory drug, however, could supply the aforesaid benefits with less antagonistic broadside effects.

THC could beryllium almighty against cognitive diminution erstwhile combined with an anti-inflammatory, a caller survey suggests. (iStock)

The study, which was published successful the diary Aging and Disease, paired low-dose THC extract with celecoxib, which was administered to mice regular for 30 days.

The mice received the treatments earlier the improvement of representation symptoms to measurement the interaction connected preventing oregon delaying Alzheimer’s.

CANCER MAY TRIGGER UNEXPECTED DEFENSE AGAINST ALZHEIMER’S DISEASE, RESEARCHERS SAY

The results showed improved cognition, learning and memory, arsenic good arsenic decreased markers of neuroinflammation and reduced Alzheimer’s-related encephalon pathology, the merchandise stated.

Although THC unsocial had the aforesaid results, it besides accrued inflammatory signals, portion the operation dosage did not.

The THC and celecoxib combo improved cognition, learning and memory, portion besides decreasing markers of neuroinflammation and reduced Alzheimer’s-related encephalon pathology. (iStock)

"What truly mattered was behavior. If cognition is not improved, past the attraction doesn’t matter. And that’s wherever the operation intelligibly worked amended than THC alone," noted pb survey writer Chu Chen, Ph.D., prof successful the Department of Cellular and Integrative Physiology.

Years of probe led Chen to link the dots connected however THC tin manipulate the encephalon and wherefore it’s hard to usage safely for neurological conditions, according to UT Health.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

"When THC is given, it unexpectedly increases COX-2 successful the brain. That summation is intimately associated with learning and representation impairment," Chen said.

Both THC and celecoxib are FDA-approved for usage successful humans, which could supply a "real advantage" successful moving on to objective trials, according to UT Health.

"What truly mattered was behavior. If cognition is not improved, past the attraction doesn’t matter."

Future studies volition analyse whether the cause operation tin dilatory illness progression oregon reverse deficits aft symptoms person appeared.

CLICK HERE FOR MORE HEALTH STORIES

"This enactment has taken galore years. But present we’re astatine a constituent wherever basal neuroscience discoveries are pointing toward thing that could realistically determination into the clinic," Chen said.

Dr. Paul Saphier, a neurosurgeon and laminitis of Coaxial Neurosurgical Specialists successful New Jersey, called this probe an "exciting breakthrough with a immense imaginable interaction for patients and their families."

"We cognize that the buildup of the plaques related to Alzheimer's [beta-amyloid plaques] are the effect of chronic inflammation." (iStock)

"Neurocognitive deterioration has been linked to conditions that origin inflammation wrong the encephalon — anterior encephalon bleeds, strokes, tumors and infections," helium told Fox News Digital. "We besides cognize that the buildup of the plaques related to Alzheimer's [beta-amyloid plaques] are the effect of chronic inflammation."

"So, it makes consciousness that this operation therapy [might] assistance bounds the accumulation of this amyloid and thereby trim the progression of the disease."

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

Saphier said the drugs’ FDA support presumption is "encouraging," arsenic it whitethorn "ultimately easiness the availability for patients, if the proceedings proves successful."

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

"I look guardant to the results of this trial, arsenic good arsenic immoderate aboriginal trials that look astatine limiting the effects of chronic inflammation wrong the cardinal tense system."